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KMID : 0379520060220010031
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한국독성학회지
2006 Volume.22 No. 1 p.31 ~ p.37
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Melittin Inhibits Human Prostate Cancer Cell Growth through Induction of Apoptotic Cell Death
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Park Hye-Ji
Lee Yong-Kyoung
Song Ho-Sueb
Kim Goon-Joong
Son Dong-Joo
Lee Jae-Woong
Hong Jin-Tae
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Abstract
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It was previously found that melittin inhibited NF-{kappa}B activity by reacting with signal molecules of NF-{kappa}B which is critical contributor in cancer cell growth by induction of apoptotic cell death. We here investigated whether melittin inhibits cell growth of human prostate cancer cells through induction of apoptotic cell death, and the possible signal pathways. Melittin (0{sim}1;{mu}g/ml) inhibited prostate cancer cell growth in a dose dependent manner. Conversely related to the growth inhibitory effect, melittin increased the induction of apoptotic cell death in a dose dependent manner. Melittin also inhibited DNA binding activity of NF-{kappa}B, an anti-apoptotic transcriptional factor. Consistent with the induction of apoptotic cell death and inhibition of NF-{kappa}B, melittin increased the expression of pro-apoptotic proteins caspase-3, and Bax but down-regulated anti-apoptotic protein Bcl-2. These findings suggest that melittin could inhibit prostate cancer cell growth, and this effect may be related with the induction of apoptotic cell death via inactivation of NF-{kappa}B.
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KEYWORD
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Melittin, PC-3, Apoptotic cell death, NF-{kappa}B
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